Transfer of insulin lispro across the human placenta.
نویسندگان
چکیده
Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48 +/- microU in the maternal artery and 28 +/- 1 microU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836 +/- 220 microU.
منابع مشابه
Transfer of insulin lispro across the human placenta: in vitro perfusion studies.
OBJECTIVE Insulin lispro (Humalog), a human insulin analog, has a more rapid onset, earlier peak, and shorter duration of glucose lowering activity than regular human insulin. However, it is not known whether insulin lispro crosses the human placenta and reaches the fetus. Therefore, the objective of the present study was to examine whether insulin lispro crosses the placenta using the techniqu...
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عنوان ژورنال:
- European journal of obstetrics, gynecology, and reproductive biology
دوره 115 1 شماره
صفحات -
تاریخ انتشار 2004